Following the kiss, fans expressed outrage over Anthony's blatant disregard for his wife.
E! News added that the Venezuelan model was actually missing from the awards show, and that Anthony was not wearing his wedding band during the broadcast.
The couple married in November 2014 in the Dominican Republic.
Fortunately, it doesn't sound as if Lopez and Anthony's kiss had anything to do with the separation. A source told US Weekly, "It just was not working and they didn't have enough in common."
The Salsa singer made no mention of the split on social media. He did, however, post a string of photos of him kissing friends (male and female) with the hashtag #elbesoeffect.
Which was just odd and no one understood the purpose of.
It's sad news, but we're glad to know that our girl J.Lo had no part in this couple's undoing.
This marks Anthony's third marital separation. He was previously married to Lopez and former Miss Universe Dayanara Torres.